Johri Lab

Our research interests broadly span population genetics, statistical inference, and evolutionary genomics. We are interested in how nonadaptive evolutionary processes like changes in population size, recombination, mutation, direct and indirect effects of negative selection and factors such as genome architecture jointly shape patterns of genomic variation. Work in the lab involves employing computational and theoretical approaches, developing statistical methods, or using an empirical approach to perform evolutionary inference and ask fundamental questions in population genetics. To learn more, please check our Research page. Here are some questions that we are interested in:

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• How much do adaptive vs. non-adaptive evolutionary processes contribute to genome-wide patterns of variation?

• How does selection against deleterious mutations shape variation at linked sites? 

• What does the distribution of fitness effects of new mutations look like across species? How can we infer its shape from population-genetic data?

• What are the selective forces acting on other types of mutations like gene duplicates?

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